Seroquel:
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Seroquel dosage

ADULTS

Frequency may be increased to 3 times daily.

On the first day of therapy, you'll take 2 doses of 25 milligrams each.

On the second and third day, doses are usually increased by 25 to 50 milligrams apiece.

Doses as low as 150 milligrams a day sometimes prove effective, and daily dosage rarely exceeds 750 milligrams.

Long-term, the usual dosage is 300 to 400 milligrams a day, taken as 2 or 3 smaller doses.

Dosage is increased more gradually--and is maintained at a lower level--for older adults, those with liver disease, those prone to low blood pressure reactions, and the debilitated.

Doses of 800 milligrams or more per day have not been tested for safety.

Seroquel usually is taken two or three times daily. The dose usually is increased slowly over several days or weeks to achieve the desired effect. Seroquel can be taken with or without food.

The initial dose for bipolar disorder is 50 milligrams twice daily (100 milligrams/d). The dose can be increased by 100 milligrams/d to a daily dose of 400 milligrams/d. Most patients respond to 400-800 milligrams/d. Doses greater than 800 milligrams/d have not been studied.

The initial dose for schizophrenia is 25 milligrams twice daily (50 milligrams/d). The dose can be increased by 25-50 milligrams two or three times daily. The target dose is 300-400 milligrams/d in two or three doses. Patients respond to 150-750 milligrams/d, and doses greater than 800 milligrams/d have not been evaluated.

SCHIZOPHRENIA

Adults

The usual dosage range is 300 to 400 mg a day, divided into two or three smaller doses. Doses as low as 150 mg a day sometimes prove effective, and the dose rarely exceeds 750 mg per day. Doses above 800 mg per day have not been tested for safety. The dose is gradually increased over 4 days until the most effective dose is reached, using the following schedule: Day 1: Take 25 mg twice a day. Days 2, 3, and 4: The doctor will increase each daily dose by 25 to 50 mg, taken either two or three times a day. Day 5 and up: If needed, the doctor may increase each dose by 25 to 50 mg every 2 or more days.

BIPOLAR MANIA (SHORT-TERM TREATMENT OF ACUTE EPISODES)

Adults

The usual dosage range is 400 to 800 mg a day. Doses above 800 mg a day have not been tested for safety. The dosage will be gradually increased over 4 to 6 days until the most effective dose is reached, using the following schedule: Day 1: Take 50 mg twice a day. Day 2: The doctor will increase the dose to 100 mg twice a day. Day 3: The doctor will increase the dose to 150 mg twice a day. Day 4: The doctor will increase the dose to 200 mg twice a day. Days 5 and 6: If needed, the doctor may increase each dose by no more than 200-mg increments to a total daily dose of 800 mg.

DOSAGE ADJUSTMENT

If you have liver problems, you may be started at 25 mg a day. The doctor will increase the dose as needed in increments of 25 to 50 mg a day based on your body's response.

The dosage may also need to be lowered if you are weak, elderly, or prone to low blood pressure reactions. You may also need your dose adjusted if you're taking certain drugs, including Dilantin, Tegretol, and phenobarbital.

 

 
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